Arbeitsgruppen

Fleischmann, Bernd

Institute of Physiology I, Life & Brain Center; Faculty of Medicine

• Stem Cell Biology
• Cardiovascular Physiology and Pathophysiology
• Developmental physiology, cell physiology
• Signal transduction

• Cell culture, Cell biology, ES and iPS cell technology
• Cell Physiology (patch clamp, confocal imaging, electrode arrays, wide-field imaging)
• Integrative cardiovascular physiology (cardiac disease models)
• Generation of transgenic animals, Tetraploid complementation assays

Gieselmann, Volkmar

Institute for Biochemistry and Molecular Biology; Faculty of Medicine

• Lipid Metabolism
• Cell culture, Cell biology, ES and iPS cell technology
• Cell Physiology (patch clamp, confocal imaging, electrode arrays, wide-field imaging)
• Integrative cardiovascular physiology (cardiac disease models)
• Generation of transgenic animals, Tetraploid complementation assays

• Cell culture / bioreactor
• Protein analysis and identification
• Lipid Analysis
• MALDI TOF mass spectrometry
• LC-MS/MS with ESI-ion trap mass spectrometry
• LC MS/MS ESI Velos Orbitrap mass spectrometry

Gütschow, Michael

Pharmaceutical Chemistry I; PharmaCenter Bonn; Faculty of Mathematics and Natural Sciences

• Medicinal Chemistry

• Inhibitors of proteases and esterases

• Mechanisms of enzyme-inhibitor interactions
• Synthetic angiogenesis inhibitors
• Heterocyclic substances

• Synthesis of drug molecules
• Combinatorial chemistry, solid phase synthesis
• Assays for determining activity of proteases and esterases
• Molecular Modelling
• Molecular biological techniques

Kaupp, U. Benjamin

Center of advanced European studies and research (caesar); Faculty of Mathematics and Natural Sciences

• Biophysics of sensory systems
• Physiology of receptors and ion channels in cellular signaling
• Cell motility and chemotaxis
• Development of chemical tools for kinetic techniques in cell biology

• Cell culture

• Protein analysis and identification

• Molecular biological techniques

• Electrophysiology

• Caged compounds and photolysis

• Stopped-flow technique

• FACS

• TEM

• Multi-Photon-Microscope

• EM-Tomography

• High-resolution microscopy

König, Gabriele

Institute for Pharmaceutical Biology; Faculty of Mathematics and Natural Sciences

• Natural products chemistry and lead structure discovery
• Molecular genetics and biochemistry of natural product biosynthesis
• Microbial Biotechnology

• Isolation and Structure determination of natural products
• Isolation and cultivation of microorganisms
• Cloning of biosynthetic genes

Lamprecht, Alf

Pharmaceutical Institute; Pharmaceutical Technology; Faculty of Mathematics and Natural Sciences

• Novel drugs, micro-, nano-particles, drug targeting, protein delivery
• Drug delivery in healthy and pathophysiological altered absorption barriers

• pharmaceutical development of micro-and nanoscale systems for drug transport and related analysis
• Absorption studies on in vitro cell culture systems
• Inflammation models

Mohr, Klaus

Pharmaceutical Institute; Pharmacology and Toxicology; Faculty of Mathematics and Natural Sciences

• G protein-coupled receptor (GPCR)
• Molecular mechanisms of drug-GPCR interaction
• Allosteric modulation of GPCR

• Radioligand receptor binding studies, including allosteric / orthosteric interactions
• Data analysis based on complex receptor interaction models
• Receptor mutagenesis
• Molecular Modelling
• Isotope laboratory, and genetic engineering laboratories

Müller, Christa

Pharmaceutical Institute; Pharmaceutical Chemistry I, Faculty of Mathematics and Natural Sciences

• Medical Chemistry, Chemical Biology and Molecular Pharmacology of Purinergic receptors (adenosine, P2Y, P2X, adenine receptors)
• G-protein-coupled receptors / orphan GPCRs
• Ectonucleotidase inhibitors
• Development of screening assays

• Synthesis of drug molecules (small molecules)
• Combinatorial synthesis, microwave-assisted synthesis
• Molecular biological techniques (expression in mammalian cells, insect cells and yeast), mutagenesis studies
• Development of radioligands (including PET-ligands), fluorescent ligands and ESR probes
• Isotope Laboratories
• GM-S2-Laboratories
• NMR (500 MHz), LCMS, CE

Oldenburg, Johannes

Institute of Experimental Hematology and Transfusion Medicine; Faculty of Medicine

• Hereditary and acquired thrombophilias and haemorrhage
• Vitamine K cycle
• Anticoagulants
• Recombinant clotting proteins

• Large cohorts of patients nationwide
• GMP / clean room laboratory (under construction)
• Knockout mice
• Specialized Coagulation Laboratory
• Fully equipped molecular biology labs

Pfeifer, Alexander

Institute for Pharmacology and Toxicology, Faculty of Medicine

• NO / cGMP pathway - cGMP-dependent protein kinase, cell and animal models
• Metabolism and adipogenesis: Focus on brown fat
• Neurodegeneration - development of new therapeutic approaches and miRNAs
• Drug targeting - Nanomedicine

• Viral vector platform: Focus on lentiviral vectors, lentiviral transgenesis (production of transgenic animals using lentiviral gene transfer)
• Animal models: Lentiviral transgenesis and knockout mice
• RNA interference: siRNA-based therapeutic approaches, the role of microRNAs in neurodegeneration and stem cell differentiation
• Stem cells; focus on mesenchymal stem cell differentation

Sahl, Hans-Georg

IMMIP - Pharmaceutical Microbiology; Faculty of Mathematics and Natural Sciences and Faculty of Medicine

• antibiotic natural products (lantibiotics, lipopeptides)
• Defensins - antimicrobial peptides of defense against infections
• new antibiotic mechanism of action
• Biochemistry of cell wall biosynthesis
• Physiology and pathogenicity of staphylococci

• Microbiology
• Bacterial molecular biology
• Biochemistry
• Special antibiotics applications

Schiedel, Anke C.

Pharmaceutical Institute; Pharmaceutical Chemistry I; Faculty of Mathematics and Natural Sciences

• G-protein-coupled receptors / orphan GPCRs
• Regulation and signaling of GPCRs
• Mutagenesis of GPCRs
• Nucleoside and nucleobase transporters

• Molecular biological techniques
• Expression in bacteria, mammalian cells, insect cells and yeast
• Mutagenesis studies
• Cell biology
• PCR, qPCR
• Gene silencing
• Expression profiling
• Western Blot/ELISA
• Isotope Laboratories
• GM-S2-Laboratories

Steinhäuser, Christian

Institute of Cellular Neurosciences; Faculty of Medicine

• Analysis of neuron-glia interactions
• Role of astrocytes in human temporal lobe epilepsy
• Structure-function analysis of radial glial cells during postnatal neurogenesis in the dentate gyrus
• Neurophysiology of the hippocampus

• Patch clamp technique
• Rapid drug application
• Single cell RT-PCR (multiplex, real-time TaqMan)
• Generation and application of transgenic mice
• post-recording immunocytochemistry
• Multi photon microscopy
• Photolysis-based uncaging (Ca2+, glutamate, ATP)

Zimmer, Andreas

Institute for Molecular Psychiatry, Life & Brain Center Faculty of Medicine

• Animal models for psychiatric disorders
• Addiction, pain, mood disorders, schizophrenia
• Neuro-immune interactions
• euromodulators

• genetic manipulation of mice

• Mouse genetics

• Molecular biology, expression profiles
• microsurgical interventions in mice
• Histology / Embryology
• Immunological methods (eg, FACS analysis, bone marrow transplantation)
• High-throughput genotyping

Zimmermann, Katrin

Institute for Pharmacology and Toxicology; Faculty of Medicine

• Drug targeting - Nanomedicine

• Viral vector platform: Focus on lentiviral vectors, lentiviral transgenesis (production of transgenic animals using lentiviral gene transfer)