One Two
Kontakt

  • Dr. Elisabeth Mies-Klomfass
    c/o Institute for Pharmacology and Toxicology
    University of Bonn
    Biomedical Center
    Sigmund-Freud-Str. 25, D-53127 Bonn
    Tel.: +49 (0)228-287-51284
    Fax: +49 (0)228-287-51301
    E-Mail: biotech-pharma(at)uni-bonn.de
  • Prof. Dr. Alexander Pfeifer
    Speaker
    Institute for Pharmacology and Toxicology
    University of Bonn
    Biomedical Center
    Sigmund-Freud-Str. 25, D-53127 Bonn
    Tel.: +49 (0)228-287-51300/-51302
    Fax: +49 (0)228-287-51301
    Email: alexander.pfeifer(at)uni-bonn.de

 

 
Sie sind hier: Startseite Arbeitsgruppen

Arbeitsgruppen

Name

Research interests

Technologies / resources

Fleischmann, Bernd

Institute of Physiology I, Life & Brain Center; Faculty of Medicine

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  • Stem Cell Biology
  • Cardiovascular Physiology and Pathophysiology
  • Developmental physiology, cell physiology
  • Signal transduction
  • Cell culture, Cell biology, ES and iPS cell technology
  • Cell Physiology (patch clamp, confocal imaging, electrode arrays, wide-field imaging)
  • Integrative cardiovascular physiology (cardiac disease models)
  • Generation of transgenic animals, Tetraploid complementation assays

Gieselmann, Volkmar

Institute for Biochemistry and Molecular Biology; Faculty of Medicine

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  • Lipid Metabolism
  • Mechanism of demyelination
  • Pathogenesis and treatment of lysosomal lipid storage disorders
  • Transport mechanisms of the blood-brain barrier
  • Cell culture / bioreactor
  • Protein analysis and identification
  • Lipid Analysis
  • MALDI TOF mass spectrometry
  • LC-MS/MS with ESI-ion trap mass spectrometry
  • LC MS/MS ESI Velos Orbitrap mass spectrometry

Gütschow, Michael

Pharmaceutical Chemistry I; PharmaCenter Bonn; Faculty of Mathematics and Natural Sciences

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  • Medicinal Chemistry
  • Inhibitors of proteases and esterases

  • Mechanisms of enzyme-inhibitor interactions
  • Synthetic angiogenesis inhibitors
  • Heterocyclic substances
  • Synthesis of drug molecules
  • Combinatorial chemistry, solid phase synthesis
  • Assays for determining activity of proteases and esterases
  • Molecular Modelling
  • Molecular biological techniques

Kaupp, U. Benjamin

Center of advanced European studies and research (caesar); Faculty of Mathematics and Natural Sciences

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  • Biophysics of sensory systems
  • Physiology of receptors and ion channels in cellular signaling
  • Cell motility and chemotaxis
  • Development of chemical tools for kinetic techniques in cell biology
  • Cell culture

  • Protein analysis and identification

  • Molecular biological techniques

  • Electrophysiology

  • Caged compounds and photolysis

  • Stopped-flow technique

  • FACS

  • TEM

  • Multi-Photon-Microscope

  • EM-Tomography

  • High-resolution microscopy

König, Gabriele

Institute for Pharmaceutical Biology; Faculty of Mathematics and Natural Sciences

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  • Natural products chemistry and lead structure discovery
  • Molecular genetics and biochemistry of natural product biosynthesis
  • Microbial Biotechnology
  • Isolation and Structure determination of natural products
  • Isolation and cultivation of microorganisms
  • Cloning of biosynthetic genes

Lamprecht, Alf

Pharmaceutical Institute; Pharmaceutical Technology; Faculty of Mathematics and Natural Sciences

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  • Novel drugs, micro-, nano-particles, drug targeting, protein delivery
  • Drug delivery in healthy and pathophysiological altered absorption barriers
  • pharmaceutical development of micro-and nanoscale systems for drug transport and related analysis
  • Absorption studies on in vitro cell culture systems
  • Inflammation models

Mohr, Klaus

Pharmaceutical Institute; Pharmacology and Toxicology; Faculty of Mathematics and Natural Sciences

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  • G protein-coupled receptor (GPCR)
  • Molecular mechanisms of drug-GPCR interaction
  • Allosteric modulation of GPCR
  • Radioligand receptor binding studies, including allosteric / orthosteric interactions
  • Data analysis based on complex receptor interaction models
  • Receptor mutagenesis
  • Molecular Modelling
  • Isotope laboratory, and genetic engineering laboratories

Müller, Christa

Pharmaceutical Institute; Pharmaceutical Chemistry I, Faculty of Mathematics and Natural Sciences

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  • Medical Chemistry, Chemical Biology and Molecular Pharmacology of Purinergic receptors (adenosine, P2Y, P2X, adenine receptors)
  • G-protein-coupled receptors / orphan GPCRs
  • Ectonucleotidase inhibitors
  • Development of screening assays
  • Synthesis of drug molecules (small molecules)
  • Combinatorial synthesis, microwave-assisted synthesis
  • Molecular biological techniques (expression in mammalian cells, insect cells and yeast), mutagenesis studies
  • Development of radioligands (including PET-ligands), fluorescent ligands and ESR probes
  • Isotope Laboratories
  • GM-S2-Laboratories
  • NMR (500 MHz), LCMS, CE

Oldenburg, Johannes

Institute of Experimental Hematology and Transfusion Medicine; Faculty of Medicine

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  • Hereditary and acquired thrombophilias and haemorrhage
  • Vitamine K cycle
  • Anticoagulants
  • Recombinant clotting proteins
  • Large cohorts of patients nationwide
  • GMP / clean room laboratory (under construction)
  • Knockout mice
  • Specialized Coagulation Laboratory
  • Fully equipped molecular biology labs

Pfeifer, Alexander

Institute for Pharmacology and Toxicology, Faculty of Medicine

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  • NO / cGMP pathway - cGMP-dependent protein kinase, cell and animal models
  • Metabolism and adipogenesis: Focus on brown fat
  • Neurodegeneration - development of new therapeutic approaches and miRNAs
  • Drug targeting - Nanomedicine
  • Viral vector platform: Focus on lentiviral vectors, lentiviral transgenesis (production of transgenic animals using lentiviral gene transfer)
  • Animal models: Lentiviral transgenesis and knockout mice
  • RNA interference: siRNA-based therapeutic approaches, the role of microRNAs in neurodegeneration and stem cell differentiation
  • Stem cells; focus on mesenchymal stem cell differentation

Sahl, Hans-Georg

IMMIP - Pharmaceutical Microbiology; Faculty of Mathematics and Natural Sciences and Faculty of Medicine

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  • antibiotic natural products (lantibiotics, lipopeptides)
  • Defensins - antimicrobial peptides of defense against infections
  • new antibiotic mechanism of action
  • Biochemistry of cell wall biosynthesis
  • Physiology and pathogenicity of staphylococci
  • Microbiology
  • Bacterial molecular biology
  • Biochemistry
  • Special antibiotics applications

Schiedel, Anke C.

Pharmaceutical Institute; Pharmaceutical Chemistry I; Faculty of Mathematics and Natural Sciences

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  • G-protein-coupled receptors / orphan GPCRs
  • Regulation and signaling of GPCRs
  • Mutagenesis of GPCRs
  • Nucleoside and nucleobase transporters
  • Molecular biological techniques
  • Expression in bacteria, mammalian cells, insect cells and yeast
  • Mutagenesis studies
  • Cell biology
  • PCR, qPCR
  • Gene silencing
  • Expression profiling
  • Western Blot/ELISA
  • Isotope Laboratories
  • GM-S2-Laboratories

Steinhäuser, Christian

Institute of Cellular Neurosciences; Faculty of Medicine

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  • Analysis of neuron-glia interactions
  • Role of astrocytes in human temporal lobe epilepsy
  • Structure-function analysis of radial glial cells during postnatal neurogenesis in the dentate gyrus
  • Neurophysiology of the hippocampus
  • Patch clamp technique
  • Rapid drug application
  • Single cell RT-PCR (multiplex, real-time TaqMan)
  • Generation and application of transgenic mice
  • post-recording immunocytochemistry
  • Multi photon microscopy
  • Photolysis-based uncaging (Ca2+, glutamate, ATP)

Zimmer, Andreas

Institute for Molecular Psychiatry, Life & Brain Center Faculty of Medicine

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  • Animal models for psychiatric disorders
  • Addiction, pain, mood disorders, schizophrenia
  • Neuro-immune interactions
  • euromodulators
  • genetic manipulation of mice
  • Mouse genetics

  • Molecular biology, expression profiles
  • microsurgical interventions in mice
  • Histology / Embryology
  • Immunological methods (eg, FACS analysis, bone marrow transplantation)
  • High-throughput genotyping

Zimmermann, Katrin

Institute for Pharmacology and Toxicology; Faculty of Medicine

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  • Drug targeting - Nanomedicine
  • Viral vector platform: Focus on lentiviral vectors, lentiviral transgenesis (production of transgenic animals using lentiviral gene transfer)
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